Blood Pressure Can Help Get Customized Medicine for PTSD

Blood Pressure Can Help 
Get Customized Medicine for PTSD

Prazosin is a medication that is used primarily to treat high blood pressure, posttraumatic stress disorder (PTSD), and other anxiety disorders. Although prazosin treatment reduces PTSD symptoms in many people, approximately one-third of patients do not respond at all to treatment. And there are no evidence based studies to explain why people respond differently to treatment.
However, according to a recent study, men with higher blood pressure before starting treatment with prazosin experienced better results from this medicine. The study helped find a biomarker that can be used to predict an individual's response to drug therapy in fighting post-traumatic stress disorder.
"These findings suggest that high blood pressure is a biomarker that can contribute to a personalized medicine approach to identifying soldiers and veterans with PTSD combat eligible for prazosin," said study lead author Murray Raskind VA Puget Sound Health Care and University of Washington in Seattle.
BP may act as an immediate predictor of the response to the treatment of post-traumatic stress disorder
Blood pressure is a good biomarker that can be an excellent clinical utility providing an easily measurable and immediate predictor of response to treatment. It would also help physicians determine the role of drugs such as prazosin in the treatment of individuals' strategies.
Speaking of the efficacy of prazosin, John Krystal, editor of Biological Psychiatry, said: "It would be logical if prazosin was more effective in patients with increased activation of the norepinephrine systems.
Prazosin can prevent some of the effects of chemicals released by the body during stress, such as adrenaline and noradrenaline. Alpha-1-adrenergic receptors (α1AR) can be blocked and this mechanism may help to prevent some of the effects of such chemicals.
Since α1AR activity can not be directly measured in humans, the researchers identified a biological marker device that is regulated by α1AR activity. Stimulation by noradrenaline α1AR increases blood pressure, which means that blood pressure may be a useful indicator of α1AR activity.
The researchers analyzed the symptoms of post-traumatic stress disorder in soldiers and their blood pressure measurements previously collected as part of a randomized controlled trial of 67 soldiers who had returned from Iraq and Afghanistan. Among them, 32 participants received prazosin and 35 received placebo for 15 weeks. Blood Pressure.
"Pre-treatment systolic blood pressure strongly predicts the response to prazosin," said Raskind. At the end of the 15-week treatment period, the investigators found that participants with higher initial blood pressure saw a greater improvement in their post-traumatic stress disorder symptoms, with a better outcome for each increase of 10 mmHg -Dessus mm Hg 110.
Apart from what suggests that blood pressure may help predict what a PTSD soldier will benefit most from treatment, the results have also yielded sufficient information about the pathophysiology of the disease.
"The increase in blood pressure in these patients with PTSD may be a biological marker for patients who are more likely to benefit from prazosin, in which case it may be a useful indicator of the activation of noradrenergic activation associated with stress disorder Posttraumatic in these patients.
Blood Pressure.

Treating Anxiety Disorders
Mental health problems such as anxiety disorders should be treated with the highest priority because they can be severely harmful when ignored. Symptoms, when left untreated, can aggravate and make it difficult for patients. The best solution is to seek treatment from any credible organization in the right conditions. PTSD.

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